A REDUCTION in cancer pathology notifications during COVID-19-related restrictions means there may be thousands of additional undetected cancer cases in the community, with experts concerned there may be a coming surge in diagnoses at more advanced stages of disease.

Cancer pathology notifications are still not back at pre-COVID-19 levels, according to a study published in the MJA.

The researchers reviewed cancer pathology notifications on the Victorian Cancer Registry from 1 April to 15 October 2020. They noticed a significant decline in cancer pathology notifications during the Victorian 2020 lockdowns.

However, what has researchers worried is that as of January 2021, there still hasn’t been the surge of cancer notifications they thought they’d see following the easing of restrictions.

“We expected towards the end of the study period that we would see a greater return to normal or even see a surge in reporting,” said Professor Sue Evans, Director of the Victorian Cancer Registry and one of the study authors.

“But we haven’t seen that yet. It’s not alarming but we are a bit concerned. We’ve seen less of a decline, but we’re still seeing less observed cancer notifications than we would expect even at this point in time.”

In their MJA article, the author found that during 1 April to 15 October 2020, there were 5446 fewer notifications of new cancer diagnoses than predicted by their primary model (predicted, 54 609 v observed, 49 163; relative reduction, –10.0%).

“We estimated that there were 2530 undiagnosed cancers.”

For some cancers, such as breast cancer, there was reduced screening during the COVID-19 period. BreastScreen Victoria, for example, paused its screening services from Wednesday 25 March until Monday 11 May 2020.

“Our most recent annual report shows that we carried out 218 129 breast screens in 2019–20, in comparison to 267 589 in 2018–19 and 260 722 in 2017–18, which illustrates the reduction in screening in the last financial year to June 2020,” a BreastScreen Victoria spokesperson told InSight+.

When they reopened, they spaced their appointment times and increased infection control measures to reduce risk. These safety measures, in combination with clients receiving an invitation, saw a strong demand for appointments by the end of May 2020.

Because of this demand, reduced appointments meant there were increased waiting times for some clinics across Victoria.

A reduction in breast cancer notifications was expected because of screening services being closed; however, there were also higher reductions in notifications for prostate cancer, head and neck tumours, and melanoma.

Reductions were greater for men, people aged 50 years or more, and for people in areas of higher socio-economic status.

“When we looked at cancers that are prevalent in both males and females, we noticed again the vast majority were males,” Professor Evans said.

While GP clinics were open throughout the lockdown periods, many people may have delayed visiting unless it was urgent, or they may have used telehealth services.

While telehealth has had many advantages, its less personal nature may mean GPs don’t get the full picture as patients may not raise seemingly minor changes in their health.

“I think there’s a high likelihood that is happening,” Professor Evans told InSight+.

“It’s hard to know, but it makes sense that men particularly are not going in for general check-ups, and not getting [prostate‐specific antigen] levels taken. Those sorts of things are often deferred when you’re reluctant to go out of the house. It’s likely to play a part in why we’re seeing fewer notifications.”

New South Wales also saw a small reduction of cancer notifications, according to a NSW Health spokesperson:

“There was an approximate 3.7% reduction in electronic notifications of new cancer diagnoses to the NSW Cancer Registry in March to November 2020 compared with the months prior. We are continuing to monitor the data,” the spokesperson said.

The researchers predict that a surge of cancer cases is still to come in the next 6–12 months, and they fear it means people will present at a later, more advanced stage of the disease.

However, what that may mean is unclear.

“We really don’t know what impact this will have on cancer mortality. Some of these cancers it may not impact at all. I think it’ll be an interesting natural experiment to see what happens over time and see whether it impacts survival,” said Professor Evans.

Dr Luc te Marvelde, Head of Data Analytics at the Victorian Cancer Registry and study co-author, told InSight+, in an exclusive podcast, that impacts on stage migration was something they would keep a close eye on.

“The next step is once all the data is processed, we will have a good idea about the stage of diagnosis. We would expect there is a delay in cancer diagnoses and we would expect people to present with a higher stage with more advanced disease. Once the data is processed then we would have a good idea how this would impact survival,” he said.

The researchers hope that a combination of media campaigns and GP reassurance will help people feel confident to visit their doctor again.

“The general public need to understand that going to their GP is a safe thing to do.” Professor Evans concluded.


Poll

We can expect to see a surge in cancer diagnoses in coming months
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  • Neutral (10%, 3 Votes)
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Total Voters: 30

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