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[Review] The science of early adversity: is there a role for large institutions in the care of vulnerable children?

It has been more than 80 years since researchers in child psychiatry first documented developmental delays among children separated from family environments and placed in orphanages or other institutions. Informed by such findings, global conventions, including the 1989 UN Convention on the Rights of the Child, assert a child’s right to care within a family-like environment that offers individualised support. Nevertheless, an estimated 8 million children are presently growing up in congregate care institutions.

News briefs

Inhaled Ebola vaccine stops virus in monkeys

The New York Times reports that a single dose of a new, inhalable Ebola vaccine has neutralised the virus in monkeys. The study, conducted by University of Texas researchers, was published first in the Journal of Clinical Investigation. Four rhesus macaques were given one aerosol dose, four were given two aerosol doses and two were given the vaccine in liquid form. Two were not vaccinated, serving as controls. Four weeks after treatment, all the monkeys were given a dose of Ebola, 1000 times the fatal dose. A week later, the two unvaccinated monkeys died but the vaccinated animals remained healthy. The survivors were euthanised and their blood and tissues showed no sign of Ebola. The next step is for the National Institutes of Health to perform clinical trials on humans.

http://www.nytimes.com/2015/07/14/health/inhaled-ebola-vaccine-stops-virus-in-monkeys-study-finds.html

New CEO for Medical Deans is Carmel Tebbutt

Former New South Wales cabinet minister Carmel Tebbutt has been announced as the new chief executive officer of the Medical Deans Australia and New Zealand. She will replace incumbent Professor Judy Searle, who is retiring from the role after 2.5 years. Ms Tebbutt starts in the position on 19 October. She spent 11 years as a minister and senior member of the Cabinet in the NSW Parliament, with portfolio responsibilities across a number of areas including education and training, health, community services and the environment. “There are many challenges confronting medical education and research. I am looking forward to using my skills to forward the objectives of the Medical Deans”, Ms Tebbutt said. “One of my first tasks will be to meet with members and stakeholders to hear first-hand about the key issues for the sector.”

Tax on soft drinks: it’s working in Mexico

Health economists at the University of North Carolina in the US have studied Mexico’s 18-month-old “soda tax” and found that it is reducing consumption of sugar-heavy drinks in the country where annual consumption tops out at 163 litres per person, Wired reports. The one-peso-per-litre tax has caused a drop in consumption of an average of 6%, according to the researchers. “The decline accelerated as the year went on, reaching 12 percent by December [2014].” With plans to increase the tax to two pesos per litre, the results show that it was the poorest Mexicans who cut back on soda the most, averaging a 9% decline and peaking at 17%. Consumption of bottled water increased by 4% in the same time period. “A soda tax alone is not going to solve the entire obesity and diabetes epidemic”, the researchers concluded. Still, it might help “shift people’s mindset about these beverages. They’re not innocent”.

http://www.wired.com/2015/07/mexicos-soda-tax-working-us-learn

Non-invasive device could end finger pricking for people with diabetes

Science Daily reports on a new low-powered laser sensor that monitors blood glucose levels without penetrating the skin. Developed by a team at the University of Leeds in the UK, the device “has continuous monitoring capabilities making it ideal for development as a wearable device”. It could also be a simpler and cheaper alternative to the two current methods — finger pricking, using disposable sample strips, or invasive continuous monitors using implanted sensors that need regular replacement. “This technology opens up the potential for people with diabetes to receive continuous readings, meaning they are instantly alerted when intervention is needed. This will allow people to self-regulate and minimise emergency hospital treatment,” the researchers said.

http://www.sciencedaily.com/releases/2015/07/150714200110.htm

Retracted papers cited years after withdrawal

Retraction Watch reports that disgraced American anaesthetist Scott Reuben’s retracted papers are still being cited 5 years after retraction, and only 25% of those citations correctly acknowledge the retraction, according to a new study, published in Science and Engineering Ethics. Reuben, who fabricated data, spent 6 months in prison in 2009, and has now accumulated 25 retractions. In the new paper, the authors counted 274 citations of 20 of Reuben’s papers between 2009 and 2014, 45% of them more than once. “Our paper shows that perpetuation of retracted publications is still an ongoing problem in our scientific community… In addition, we could demonstrate that, despite the overall number of citations of retracted publications decreasing over the years, the percentage of correctly labeled citations dropped even more.”

http://retractionwatch.com/2015/07/14/half-of-anesthesiology-fraudsters-papers-continue-to-be-cited-years-after-retractions

Changing roles

Some readers have noticed changes at the MJA. I am pleased to mind the store until the appointment of a new Editor-in-Chief, well aware of the achievements at the Journal of Emeritus Professor Stephen Leeder, AO, in recent times. As a member of the Editorial Advisory Committee, I salute Steve’s contribution to the Journal.

One change planned in recent months is the one-page summary of research articles. This follows similar practices in international journals and responds to our continued discussion with our audience. This makes the research articles shorter, clearer and straight to the point, and also provides an opportunity to further explore and expand the original data online. The introduction of this format now represents part of the transition to electronic publication of the Journal. You are invited to comment.

More generally, I would be delighted to hear directly from any reader who has constructive suggestions for improving the Journal. As Interim Editor, I expect to serve more as an umpire in decisions at the Journal than as a shaper of its future. But I will, of course, share any emerging, creative ideas with the next Editor-in-Chief.

Emails to cguest@mja.com.au will be considered in confidence. Depending on the volume of suggestions, I will reply. If you wish to publish your thoughts in the Journal, please refer, as always, to our Instructions to Authors. Depending on the length and format of your submission, the usual rules of peer review may apply.

Long live the Medical Journal of Australia!

[Correspondence] Data donation after death

Sheila Bird (May 9, p 1830)1 recently pointed out how late registration of death in England and Wales seriously disabled statistical and epidemiological studies. Another serious obstacle to essential observational research is the accessibility of precious medical data after a person’s death. To prevent waste of medical research data, we suggest that all citizens should be encouraged to donate data after death just as people donate organs posthumously, as was previously suggested in relation to brain researchers’ personal data.

[Correspondence] Is crowdfunding a viable source of clinical trial research funding?

As public research grants for randomised controlled trials (RCTs) have diminished and become increasingly competitive, researchers have to search for alternative funding sources. Crowdfunding, in which projects are funded directly from the public through the internet, might represent a potential source of RCT funding.1 However, whether or not crowdfunding campaigns for clinical RCTs are successful is unclear.

[Editorial] Paying a high price for cancer drugs

Results of research from the early Breast Cancer Triallists’ Collaborative Group in Oxford, UK, published in The Lancet on July 24, 2015, were encouraging. They showed that use of adjuvant bisphosphonates in the treatment of early breast cancer in postmenopausal women could reduce disease recurrence and mortality. Bisphosphonates, available in generic form, are inexpensive and should be available worldwide to improve care in this population.

[Perspectives] Global Health Film Festival: media, impact, and social change

Telling the stories of people through film, television, radio, and other media is important for witnessing the realities of individuals’ lives in different settings and for promoting social change. Media campaigns can play a part in stimulating behaviour change and improving the uptake of health interventions, although measuring the effect of such campaigns remains a challenge. Interesting work is currently underway by researchers from the London School of Hygiene & Tropical Medicine (LSHTM) on a media campaign in sub-Saharan Africa that aims to help prevent and treat malaria, diarrhoea, and pneumonia in children, as well as encourage women to attend health facilities for childbirth.

[World Report] Profile: The Liggins Institute, New Zealand

Named after Graham ‘Mont’ Liggins—who proved steroid treatment to accelerate lung development could help premature babies survive—the Liggins Institute at the University of Auckland, New Zealand, focuses on early life development and research across the life course. Peter Gluckman— who founded the Liggins in 2002 and is now Chief Science Advisor to the New Zealand Prime Minister—said back then that “New Zealand must have a critical mass of scientists doing world class research”. And so, with colleagues including Wayne Cutfield and Jane Harding who remain with the institute today, and backed by the late Mont Liggins, Gluckman launched the institute.

Nation pays high price for unnecessary tests, unproven treatments

Cracking down on inefficient and clinically unnecessary practices like over-ordering diagnostic tests, prescribing inappropriate medications and using unproven or speculative treatments could save the health system more than $15 billion a year, a leading epidemiologist has said.

In a provocative speech to the AMA National Conference in which he called for a transformation in the way in care is conceived and delivered, Associate Professor Ian Scott said up to 30 per cent of health spending was wasteful or went on procedures and treatments that were of little benefit or could actually be harmful.

A/Professor Scott, who is director of Internal Medicine and Clinical Epidemiology at Brisbane’s Princess Alexandra Hospital, said while some interventions and treatments, like vaccination programs, public health campaigns, chemotherapy, renal dialysis and some cancer screening programs were effective uses of scarce health funds, the pay-off from many other practices was more questionable.

He questioned the bias in the medical profession to provide intensive care, including “heroic interventions”, for very ill patients – 30 per cent of health funds are spent on health care in the last year of life, including $2.4 billion on providing hospital care to the elderly – and suggested a more conservative approach involving a shift in focus away from treatments that do not improve survival beyond six months or enhance quality of life.

One of the oft-cited sources of inefficiency and cost blow-outs in the health system is in the area of diagnosis, including the tendency to over-prescribe diagnostic tests.

Much of this has been attributed to the rise of “defensive medicine”, which MDA National Manager of Medico-legal and Advisory Services, Dr Sara Bird, defined as the ordering of treatments, tests and procedures “primarily to help protect the doctor from liability”, rather than to substantially advance patient diagnosis or treatment.

Dr Bird, who addressed the same AMA National Conference policy session as A/Professor Scott, said that although the incidence of defensive medicine was difficult to measure, evidence suggested it was widespread.

In the United States, 96 per cent of specialists practising in fields at high risk of litigation confessed to practising defensively, including 43 per cent who reported ordering unnecessary diagnostic imaging tests.

Dr Bird said the situation appeared to be similar in the United Kingdom, where almost 80 per cent of hospital-based doctors said they practised defensive medicine, including 60 per cent who admitted ordering unnecessary tests and 55 per cent who said they made unnecessary referrals.

In Australia, research indicates that doctors who have been the subject of legal action are much more likely to practise defensively – 55 per cent ordered more tests and 43 per cent made more referrals than was considered usual.

A/Professor Scott said that in addition to unnecessary tests, often clinicians provided treatments that were of little or no value.

He lauded the National Prescribing Service’s Choosing Wisely initiative, under which so far more than 200 routinely used treatments have been placed under scrutiny.

The Federal Government has also commissioned a review of Medicare Benefit Schedule items, led by Sydney Medical School Dean Professor Bruce Robinson, to scrutinise and assess the appropriateness of more than 5500 listed services.

AMA President Professor Brian Owler has cautiously welcomed the reviews.

Professor Owler said that although it was important to rigorously assess the value and appropriateness of procedures and treatments, it was vital the process was not driven primarily a search for savings, and that it had the support and involvement of medical colleges and societies.

A/Professor Scott warned of “indication creep”, where a treatment proved to be of benefit to one group of patients is uncritically applied more broadly , such as cardioverter defibrillators, cardiac resynchronisation pacemakers and transcatheter aortic valves.

He urged a much more considered and cautious approach to the use of new interventions until there was rigorous evaluation of their safety and effectiveness.

A/Professor Scott said told the conference that clinical guidelines should take into account cost-effectiveness in recommending interventions.

He said often less intensive and cheaper management regimes for conditions such as bleeding peptic ulcers and urinary tract infections in children were just as safe and effective as higher-intensity regimens.

A/Professor Scott recommended that analyses of the comparative cost effectiveness be an integral part of the assessment of each new service or intervention.

He told the conference this cost-effectiveness approach should also inform the selection of patients for a particular treatment.

The epidemiologist said interventions should be targeted to those who would derive greatest benefit.

Adrian Rollins