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[Correspondence] Improving the quality and coverage of cancer registries globally

The Global Burden of Disease (GBD) 2013 report1 provides mortality estimates for 240 causes of death but also incorporates several criticisms of the methods used by the International Agency for Research on Cancer (IARC) in developing national estimates of cancer incidence and mortality worldwide in GLOBOCAN.2 We remain encouraged by the overall comparability of the two sets of estimates, yet IARC’s approach differs from that of GBD, and warrants further comment.

[Correspondence] Improving the quality and coverage of cancer registries globally – Authors’ reply

We have noted key differences between the cancer estimation approaches in the Global Burden of Disease (GBD) Study and the International Agency for Research on Cancer (IARC) project GLOBOCAN,1,2 which Freddie Bray and colleagues have taken issue with. With regard to data, the GBD uses all the data reported by the IARC plus cause of death data from vital registration systems and other sources, along with cancer registries not collated by the IARC. However, the most important distinction concerns estimation methods.

[Perspectives] Eva Harris: making science democratic, and sustainable

It was while peering down a microscope at high school that Eva Harris first became fascinated with the possibilities that science could offer. “I am still amazed by the beauty of the structure and processes of the human cell”, she says. “I think of the cell as a molecular corollary of human life, with so many different structures and functions working together for the greater good of the whole.” Today, Harris seems well suited to the environs of the University of California at Berkeley, her professional home for the past 17 years, where she is Professor of Infectious Diseases and Global Health, Director of the Center for Global Public Health, and a leading expert in dengue research.

Effect of older age on treatment decisions and outcomes among patients with traumatic spinal cord injury [Research]

Background:

Older people are at increased risk of traumatic spinal cord injury from falls. We evaluated the impact of older age (≥ 70 yr) on treatment decisions and outcomes.

Methods:

We identified patients with traumatic spinal cord injury for whom consent and detailed data were available from among patients recruited (2004–2013) at any of the 31 acute care and rehabilitation hospitals participating in the Rick Hansen Spinal Cord Injury Registry. Patients were assessed by age group (< 70 v. ≥ 70 yr). The primary outcome was the rate of acute surgical treatment. We used bivariate and multivariate regression models to assess patient and injury-related factors associated with receiving surgical treatment and with the timing of surgery after arrival to a participating centre.

Results:

Of the 1440 patients included in our study cohort, 167 (11.6%) were 70 years or older at the time of injury. Older patients were more likely than younger patients to be injured by falling (83.1% v. 37.4%; p < 0.001), to have a cervical injury (78.0% v. 61.6%; p = 0.001), to have less severe injuries on admission (American Spinal Injury Association Impairment Scale grade C or D: 70.5% v. 46.9%; p < 0.001), to have a longer stay in an acute care hospital (median 35 v. 28 d; p < 0.005) and to have a higher in-hospital mortality (4.2% v. 0.6%; p < 0.001). Multivariate analysis did not show that age of 70 years or more at injury was associated with a decreased likelihood of surgical treatment (adjusted odds ratio [OR] 0.48, 95% confidence interval [CI] 0.22–1.07). An unplanned sensitivity analysis with different age thresholds showed that a threshold of 65 years was associated with a decreased chance of surgical treatment (OR 0.39, 95% CI 0.19–0.80). Older patients who underwent surgical treatment had a significantly longer wait time from admission to surgery than younger patients (37 v. 19 h; p < 0.001).

Interpretation:

We found chronological age to be a factor influencing treatment decisions but not at the 70-year age threshold that we had hypothesized. Older patients waited longer for surgery and had a substantially higher in-hospital mortality despite having less severe injuries than younger patients. Further research into the link between treatment delays and outcomes among older patients could inform surgical guideline development.

[Correspondence] Causes of child death estimates: making use of the InterVA model

The Correspondence (June 20, p 2461)1 discussing the causes of child death estimates from both the Maternal and Child Epidemiology Estimation (MCEE) group and the Global Burden of Disease (GBD) study2 is welcome because the understanding of complex global estimates depends crucially on transparent debate and methodological comparisons.

[World Report] Profile: Joslin Diabetes Center, Boston, MA, USA

The Joslin Diabetes Center has a long history of being on the cutting edge of diabetes care and research. It was founded 117 years ago by Elliott Joslin, a physician dedicated to understanding and treating type 1 diabetes in young people. He used the latest methods to treat the disease—which at that time mainly meant enforcing a starvation diet—but was quick to adopt new techniques, said John Brooks, the centre’s current president.

[Perspectives] George King: research leader at the Joslin Diabetes Center

Like many medical researchers, George King has a personal connection to the disease that he has spent his career studying. He has been working to understand and treat diabetes at the Joslin Diabetes Center in Boston, MA, USA, since 1981, partly because of how it has affected his own family. “Asians develop diabetes at a high rate even at low body-mass index”, he says. “So many members of my family, including my father, have developed diabetes.”

e-cigarettes – what is the damage?

There has been a lot of debate about whether electronic cigarettes are the best technological solution to the smoking pandemic or the biggest looming threat to public health.

E-cigarettes are battery-powered devices that deliver nicotine to the user through a vapour by heating a solution of propylene glycol or vegetable glycerin, flavouring, and other additives. Flavours range from butter rum to caramel macchiato to strawberry lemonade.

The US Centre for Disease Control and Prevention reported earlier this year that the use of e-cigarette devices among middle school and high school students tripled between 2013-2014, with around 13 per cent of students using the devices. This surpasses the number of teens who smoke conventional cigarettes in the US.

Currently, there are more than 500 e-cigarette brands and more than 7000 flavours, and they all work in different ways to deliver varying amounts of nicotine, toxins, and carcinogens. With most e-cigarette studies funded or otherwise supported, influenced by manufactures of e-cigarettes, the current evidence base on e-cigarettes is very poor.

Julia Belluz from Vox recently examined more than 60 articles, studies, and reviews, and interviewed nine researchers and health experts to try and determine whether e-cigarettes were actually safe.  You can read her detailed findings at. http://www.vox.com/2015/6/26/8832337/e-cigarette-health-fda-smoking-safety

She found that the health effects of e-cigarettes were unclear because of the lack of credible research. But she said that so far the short-term exposure to e-cigarettes doesn’t appear to carry any serious side effects, however the research is still early.

She found that e-cigarettes were mostly composed of nicotine and a nicotine solvent (propylene glycol or vegetable glycerin) and that the levels of toxicants and carcinogens in e-cigarette vapour were nine to 450 times less prevalent than in conventional cigarette smoke. Though propylene glycol and glycerin are generally considered safe substances, not a lot is known about the long-term effects of daily inhalation.

Most researchers were inclined to cautiously say that e-cigarettes were safer than regular cigarettes because the immediate harms of e-cigarettes appear to be minimal compared with regular cigarettes.

Co-Director of the US Center for the Study of Tobacco Products Thoman Eissenberg said that its probably fair to say that a long term e-cigarette user is not going to die from tobacco-caused diseases, but it’s not clear whether they will die from an e-cigarette caused disease and whether their rates of death will be less than, more than, or the same as the rates of death we see from tobacco-caused diseases.

Australian law doesn’t ban e-cigarettes but we have strong regulations regarding the potential therapeutic use. E-cigarettes must be registered via the Therapeutic Googs Administration and liquid nicotine has to have a prescription.

The AMA has written to the Federal Health Minister Sussan Ley to encourage the tightening of legislation around the use of e-cigarettes, concerned that they are targeted towards younger consumers.

The AMA is asking for:

·         the introduction of laws to prohibit the advertising of e-cigarettes as per the prohibition on advertising of tobacco products;

·         enforcement of laws that prohibit the advertising of e-cigarettes as a therapeutic good, specifically as an aid to cessation; and

·         the prohibition of marketing of e-cigarettes to people under the age of 18.

The AMA has considerable concern about the increasing control of e-cigarettes by the tobacco industry, as Big Tobacco continues to invest heavily in the development and promotion of e-cigarettes.

 

Kirsty Waterford

Image by Vaping360 on Flickr, used under Creative Commons licence

Profession united in approach to MBS Reviews

The AMA last month convened a high-level Roundtable of the medical colleges, associations, and societies to discuss the profession’s involvement in, and response to, the Government Reviews of items on the Medicare Benefits Schedule (MBS).

The meeting was attended by over 70 people, representing 53 organisations.

Professor Bruce Robinson, Chair of the MBS Review Taskforce, made a presentation to the meeting and responded to questions from the floor.

Following the meeting, AMA President Professor Brian Owler wrote to Health Minister Sussan Ley to inform her that the profession would be united in its response to the Reviews, and outlined some of the major concerns arising from the meeting.

Here is the text of that letter …

I am writing to you to set out broad concerns with the Medicare Benefits Schedule (MBS) Reviews: the broadened scope that will impact long standing arrangements; the composition of the review working groups; and that new items are out of scope.

The AMA is concerned that the Reviews will be undertaken in the absence of an overarching vision and specific direction for the Australian healthcare system to guide the final outcomes. 

In addition, as there are no specific and quantifiable aims, other than delivering better patient outcomes, there is a risk that the scope of the reviews will extend into dangerous territory, whereby the fundamental structure of our healthcare system will be interfered with.

The latter was highlighted in Professor Bruce Robinson’s presentation to a forum of the medical colleges, specialist associations, and societies convened by the AMA on 19 August 2015 to discuss the medical profession’s involvement in the MBS Reviews.  Professor Robinson made a presentation to the group and very generously answered all of the participants’ questions.

We learnt that the Reviews will now also consist of groups to review “macro issues and rules”, and that this will consider issues such as referral arrangements and the potential removal of surgical assistance fees. We heard that patients find it inconvenient to visit their GP for a referral to a specialist. Given that the referral arrangements are the most fundamental feature of our healthcare system, providing the gateway to clinically necessary tertiary care, it is incredible that such a change might be contemplated in an environment where Government wants to reduce expenditure. 

In addition, the surgical assistance fees support the very basis of vocational training in Australia. Removal of them will have a significant impact on the training opportunities and therefore the future medical workforce. It is equally incredible that a change to these arrangements is being contemplated.

On both these issues it is not clear what the objective is, and therefore why they would even be on the table for review.

The 70 participants representing 53 medical organisations at the AMA forum were extremely vexed by this latest turn of events.

Working groups

The profession is very concerned that the working groups will not comprise a representative from the relevant specialist college, association or society. While working group members will be able to “confer with colleagues”, it is more appropriate for professional organisations to be formally included in the working groups. We believe this is critical to professional buy‑in to the outcomes of the Reviews, as well as continuity of the professions’ participation in the ongoing maintenance and management of the MBS into the future. 

Further, there are potential problems with the members of the in-scope speciality discipline comprising less than 50% of the working group numbers, with decisions to be made using a >60% majority. The equation has the potential to arrive at incorrect outcomes because the members of the speciality discipline with the knowledge and expertise will be in the minority. We appreciate the need to transparently manage conflicts of interest, but this should not be at the expense of arriving at sensible outcomes in the decision making process. 

New items

The medical profession supports an MBS that facilitates patient access to evidence based modern medical procedures and practice. This cannot occur if the review process is limited to removing obsolete and infrequently used items, and working groups are not able to consider and recommend the inclusion of new items on the MBS. While there is scope to update items, this may not always be the best way to bring the MBS up to date, and the objectives of the Reviews will be only partly achieved. 

In many cases, completely new items for procedures that have evolved in the 20+ years since they were first included on the MBS will be the only sensible outcome. If this is not resolved, the Reviews could thwart patient access to services that have been provided for several years even though they are not explicitly catered for in existing items. If the rapid review questions are appropriately framed, these services should be substantiated by the relevant literature.

There must be capacity to include new items on the MBS as a result of the reviews, which does not involve a full health technology assessment and consideration by the Medical Services Advisory Committee.

Professor Brian OwlerAMA President

Based on discussions at the MBS Roundtable, the AMA compiled the following list of issues for medical colleges, associations and societies to consider and discuss in preparing for the Reviews.

1.         Identify how the MBS should be changed to reflect current practice

  • Identify current practice for specific services.
  • Describe those services and the clinical circumstances for which they are intended.
  • Identify how the MBS currently covers those procedures.
  • Determine what is needed for the MBS to properly reflect current practice.
  • Identify services that are new due to ‘evolution’ and therefore require an update to the item descriptor compared to ‘novel’ services where there is new technology used.
  • Identify the time period in which the ‘novel’ service/s was introduced in your practice.
  • Identify items that can be deleted and the reasons for deleting them.
  • Frame the questions that will form the literature review.
  • Determine what data you need to demonstrate/inform the changes.

2.         Identify the key participants

  • Identify who of your colleagues is best placed to represent you.
  • Identify the craft groups that also provide the services.
  • Identify the craft groups that do not provide the services, but whose clinical practice might be affected.
  • Anticipate how they might respond.

3.         Identify other issues

  • Are there quality considerations?
  • Are there compliance issues?
  • What are the likely impact on business structures of the changes and what transition is needed?

4.         Guiding principles for participating in the reviews

  • Ensure services support best practice, provides value for public expenditure and supports quality, safe and effective care that is appropriate to the patient’s needs and circumstances.
  • Avoid limiting services to specific specialties, expertise, scope of practice, credentialing, and/or endorsement arrangements.  If there are safety and quality issues, consider how these can be best dealt with i.e. medical registration and/or hospital credentialing arrangements.
  • Accept the MBS rebates are inadequate. The reviews are not the vehicle to address inadequate rebates, and certainty not at the expense of another specialty group.
  • Share information about the reviews to ensure consistent outcomes and clinician participation throughout the review process.

The MBS Review Taskforce is seeking nominations from clinicians to participate in clinical committees and working groups. The Taskforce is seeking people who have sound clinical knowledge and experience, are committed to interpreting evidence and research, and are interested in furthering the objectives of the Review. Nominations can be made to MBSReviews@health.gov.au providing the name, position, clinical expertise, and email contact.

Information about the reviews can be found at

http://www.health.gov.au/internet/main/publishing.nsf/Content/healthiermedicare


John Flannery