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Inquiry into sleep health awareness

The House of Representatives Standing Committee on Health, Aged Care and Sport has commenced an Inquiry into Sleep Health Awareness in Australia.

It has been estimated that about 7.4 million Australians do not get enough sleep.

Inadequate sleep can impact on a person’s health and wellbeing, and may also lead to a loss of workforce productivity. Deloitte Access Economics assessed the health system costs associated with inadequate sleep to be about $1.8 billion in 2016-17.

Committee chair Trent Zimmerman MP said: “The Committee will examine the causes, economic and social costs, and treatment of inadequate sleep and sleep disorders – in addition to education and training available to medical professionals regarding sleep health issues, and current research into sleep health.

“The Committee will also consider workplace awareness of inadequate sleep and sleep disorders, particularly for shift workers.”

Submissions from interested individuals and organisations are invited by Thursday October 18, 2018. The preferred method of receiving submissions is by electronic format lodged online at the My Parliament website.

Further information about the Committee’s inquiry, including the full terms of reference and details on how to lodge a submission are available on the Committee’s website https://www.aph.gov.au/SleepHealth.

Too many people in the world not active enough to stay healthy

A quarter of the world’s population is not active enough to stay healthy, according to new research by the World Health Organisation.

In wealthier nations, the figure is even higher.

Australia ranks 97th in the world (out of 168) for the number of people getting enough physical activity.

The study found that 30.4 per cent of Australian adults do not engage in the recommended amount of activity to stay healthy.

The minimum amount recommended by the WHO is 150 minutes of moderate physical activity a week, or 75 minutes of vigorous physical activity per week.

The research, first published in the Lancet Global Health journal, found that about 1.4 billion adults across the globe were not physically active enough to keep in good health, with one in three women and one in four men not exercising sufficiently or even moving about enough.

In affluent countries, about half as many people are physically active as those in poorer countries.

In the developing world, many people are involved in physical labour every day, while greater wealth often equates to a more sedentary lifestyle.

These astonishing results indicate that more people are at risk of serious health problems like heart disease, type 2 diabetes, cancer and dementia.

Kuwait has the highest rate of inactivity, however, at 67 percent, followed by American Samoa and Saudi Arabia both, at 53 per cent, and Iraq at 52 per cent.

In the UK, 40 per cent of women and 32 per cent of men do not move enough. In the US, it is 48 per cent of women and 32 per cent of men. 

The study involved 1.9 million people in 168 countries, with participants self-tracking their activity in 2016. Once analysed and aggregated, the results meant about a quarter of the earth’s population are at risk of poor health due to insufficient physical activity.

   

Aiming to unlock a kidney mystery

The remaining kidney of a donor often grows in order to compensate for the loss, allowing the donor to live on without complication.

It is somewhat unknown how this occurs, but a new research project aims to unravel the mystery and help people who suffer from reduced kidney function.

Professor Jonathan Gleadle from Flinders University intends to uncover exactly how a remaining kidney grows and increases its output to function at around 80 percent of the capacity of the previous two.

“The remaining kidney in a donor has a natural ability to compensate for the loss of the other, however the key initiators of this response are unknown,” Professor Gleadle said.

“Recent evidence indicates that this growth is in response to an initial sensing mechanism, and there is strong reason to consider microRNAs play a significant role.”

MicroRNAs are specific molecules released from cells under stress that serve as messengers, telling cells how to behave. They are known to play a role in basic cell processes, with the loss or unusual expression of MicroRNAs already associated with several diseases, including diabetes and kidney disease.

“Our team aims to identify the expression of circulating microRNAs using a novel technique which will enable us to investigate hundreds of miRNAs simultaneously after the removal of a kidney.” Prof Gleadle said.

“The ultimate aim of our research is to see new treatments that can trigger healthy kidney growth in diseased patients and remove or delay the need for dialysis and transplants.”

Up to ten percent of the global population suffers from chronic kidney disease, and in Australia, 53 people die from kidney-related disease each day.

It is estimated that the economic cost of treating kidney disease in the decade to 2020 will reach about $12 billion, indicating an urgent need to invest in research to develop new strategies and treatments.

Prof Gleadle was awarded a $50,000 grant from Kidney Health Australia to progress his research.

 

 

 

 

 

 

 

Hair reading for mental health

Children’s hair could help identify their mental health.

At least that is what a groundbreaking Townsville-based research project is investigating.

A James Cook University medical researcher hopes to pave the way for earlier and more accurate identification of mental health disorders in children by reading their hair.

Dr Hani Mikhail’s is examining the potential for the measurement of cortisol, a stress-related hormone stored in hair, to help screen children for a range of mental conditions, as well as flag those at risk of developing one.

“The current model of mental health relies on analysing symptoms and their impact on a patient’s life, then trying to figure out what is going on at a psychological level,” he said.

“There is no way of looking beneath the surface, and treatment can involve a long process of trial and error.

“Cortisol is the primary chronic stress hormone of the endocrine system, and assists in the fight, flight or freeze response. As a bio marker, it may assist in reducing treatment delays, by helping to flag mental illnesses before symptoms even arise.

“This is particularly important in the context of child psychiatry, as symptoms are a lot more non-specific and early interventions often have life-long ramifications.”

The Rockhampton Base Hospital intern began his research as an honours student last year.

Dr Mikhail’s study is the first Australian research project to trial the collection and analysis of hair cortisol from children visiting a mental health facility.

His primary goal is to see hair cortisol employed as a diagnostic tool to screen and identify children at risk, before they tip over the edge.

“Ultimately, my colleagues and I want to see hair cortisol enable clinicians to detect if a child is brewing a mental health disorder, before they show any symptoms – so they can intervene to prevent something bad happening later on,” he said.

Since December last year, Dr Mikhail has collected hair samples and background questionnaire data from more than 150 children, aged five to 18, who have attended the Child and Youth Mental Health Service in Townsville.

Each child has contributed strands of hair at least three centimetres in length for analysis.

“Just like a tree, when you cut it down and can see the rings which record each year of growth, each centimeter of hair collected is roughly equivalent to one month of growth,” Dr Mikhail said.

“So we can analyse the cortisol level in a particular segment of hair and say, three months ago, this is what your average stress level was like. What was happening then?”

Previous studies have indicated that cortisol levels can change significantly in response to stress imposed by an existing mental health disorder, or due to external stress factors that could herald the onset of a mental health problem.

Conditions such as depression and psychosis raise cortisol levels, while anxiety disorders actually do the opposite.

“Bizarrely enough, Post Traumatic Stress Disorder, anxiety and eating disorders all tend to decrease the hair cortisol,” Dr Mikhail said.

“The theory is that these people have been chronically stressed for so long that the endocrine system begins to tire and starts to suppress itself.”

About half of the study participants initially assessed by the Townsville clinic were accepted for treatment.

The current phase of the study will examine hair cortisol samples to see if they predict which children were deemed in need of clinical assistance.

Dr Mikhail’s work is being supervised by JCU neuroscientist, Professor Zoltan Sarnyai, and JCU’s Head of Psychiatry, Professor Brett McDermott.

[Editorial] GLOBOCAN 2018: counting the toll of cancer

On Sept 12, the International Agency for Research on Cancer published the GLOBOCAN 2018 estimates of worldwide incidence and mortality for 36 cancers and cancer overall. Behind the data, gathered from local registries representing 185 countries, are the stories of 18·1 million people diagnosed with cancer in 2018 and the sorrow of 9·6 million deaths.

[Correspondence] What must be the role of INSERM in French biomedical research?

The major criticism raised in an Editorial (June 16, p 2390)1 was the suggestion that the renewal of the Chief Executive Officer (CEO) at the French National Institute of Health and Medical Research (INSERM) lacks transparency, since the candidates for the position are not known. This suggests that the practice does not support an “open and transparent nomination process”.1 One must remember that in France, candidates are protected by the legal framework; they are auditioned and judged by a jury, and a candidate is proposed to the appropriate ministry.

[Correspondence] The future of end-of-life care

Not much in life is certain, but death is an inevitability we all share. Because of advances in modern medicine and increasing life expectancy, population ageing is affecting developed nations, and, increasingly, the developing world. This change brings higher prevalence of chronic diseases and multimorbidity, highlighted in an Editorial (April 28, p 1637)1 as an emerging priority for global health research. Less often discussed are the implications of these global trends for death and dying, which will become more common and more complex.

[Perspectives] Louise Kenny: pioneer in maternal and perinatal health

Louise Kenny started searching for early predictors of pre-eclampsia almost two decades ago. Today, her research offers the tantalising prospect of an early pregnancy screening test. “It’s biomarker based only, it’s done at 15 weeks, it doesn’t need any clinical or scan information, and if it’s as accurate as we think it is from our preliminary work, then it’s going to be a really useful tool in the antenatal clinic”, says Kenny, Executive Pro-Vice-Chancellor of the Faculty of Health and Life Sciences at the University of Liverpool, UK, and Consultant and Professor of Obstetrics and Gynaecology at University College Cork in Ireland.

New appointments to Cancer Australia Advisory Council

Health Minister Greg Hunt has appointed six new members to the Cancer Australia Advisory Council, including high-profile AMA member Associate Professor Kelvin Kong.

The new Advisory Council members appointed for three years are:

  • Distinguished research scientist Professor Joanne Aitken
  • Gynaecological oncologist Associate Professor Penny Blomfield
  • Leading Indigenous Otolaryngologist Associate Professor Kelvin Kong
  • Consumer advocate Lillian Leigh
  • Radiation oncologist Dr Serena Sia
  • Former NSW Minister for Health the Honourable Jillian Skinner

 “I warmly welcome to the new members and look forward to working with them in the unrelenting fight against cancer,” Mr Hunt said.

“I’m confident that all members will bring their expertise in helping our country combat cancer.”

The Minister also said he was proud of the majority female representation on the Advisory Council with eight of 13 members being women.

The Cancer Australia Advisory Council provides strategic advice to support Cancer Australia in the performance of its functions.

This includes providing national leadership to reduce the impact of cancer, addressing disparities and improving outcomes for people affected by cancer.

“I am also delighted to announce that Professor Bob Thomas OAM has been reappointed as chair of the Cancer Australia Advisory Council, along with other Council members Dr William Glasson AO, Professor Dorothy Keefe PSM, and Perry Sperling PSM,” Mr Hunt said.

“I want to thank the outgoing members of the Advisory Council Michelle Ace, Keri Huxley OAM, Dianne Rule, Dr Judith Soper and Professor George Yeoh for their highly valued contribution.”

[Perspectives] Anne Chang: a champion of childhood lung health

At a health centre in Melbourne for Aboriginal and Torres Strait Islanders in the late 1980s, medical student Anne Chang had her eyes opened to Indigenous disadvantage in Australia. “The patients there had diseases not seen in mainstream medicine”, she says. “Pus from the children’s ears and chronic cough with purulent nasal discharge were common.” It was one of many experiences of health inequities that helped drive her passion for improving the health of disadvantaged groups. “People who are worse off should be given the best care”, says Chang, now Professor and Head of the Child Health Division at Menzies School of Health Research in Darwin and Consultant Paediatric Respiratory Physician at Children’s Health Queensland Hospital in Brisbane.