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[Comment] Cardiology: a call for papers

The Lancet is planning a special issue to coincide with the European Society of Cardiology Congress to be held Aug 27–31, 2016, in Rome, Italy. We will consider high quality original research papers that will influence clinical practice, especially those that describe the results of randomised trials. If your work is being presented at the meeting and falls under an embargo policy, please tell us the date, time, and manner or presentation (poster or oral). If your paper is accepted, publication on our website can be scheduled to coincide with the presentation.

[Articles] Calcium upregulation by percutaneous administration of gene therapy in patients with cardiac disease (CUPID 2): a randomised, multinational, double-blind, placebo-controlled, phase 2b trial

CUPID 2 is the largest gene transfer study done in patients with heart failure so far. Despite promising results from previous studies, AAV1/SERCA2a at the dose tested did not improve the clinical course of patients with heart failure and reduced ejection fraction. Although we did not find evidence of improved outcomes at the dose of AAV1/SERCA2a studied, our findings should stimulate further research into the use of gene therapy to treat patients with heart failure and help inform the design of future gene therapy trials.

[Editorial] Cardiology technology—from old to new

Today’s Lancet brings together a collection of cardiology research and commentary ahead of the American College of Cardiology (ACC) Annual Meeting, Chicago, IL, USA (April 2–4). The theme of this year’s meeting is ignite innovation, as the ACC invites delegates to think in new and disruptive ways, in the context of current rapid technological change.

[Correspondence] Global platform to inform investments for health R&D

Investments in health research and development (R&D) are still insufficiently aligned with global public health demands and needs. As little as 1% of all global funding for health R&D is allocated to diseases mostly noted in low-income and middle-income countries, such as malaria and tuberculosis,1 even though these diseases account for more than 12·5% of the global burden of disease.2 The 2014–15 Ebola outbreak exposed the paucity of investment in products and approaches to prevent and minimise the effect of pathogens with epidemic potential.

[Perspectives] Soumya Swaminathan: re-energising tuberculosis research in India

Paediatrician and clinical scientist Soumya Swaminathan is best known for her groundbreaking research on tuberculosis (TB). Last year, much to her surprise, she was appointed Director General of the Indian Council of Medical Research (ICMR) and Secretary of the Department of Health Research (Ministry of Health and Family Welfare) of the Government of India. Swaminathan is only the second woman to lead the ICMR, which was established in 1911, and the only woman to currently head any government science agency in India.

[Review] Evidence for effective interventions to reduce mental-health-related stigma and discrimination

Stigma and discrimination in relation to mental illnesses have been described as having worse consequences than the conditions themselves. Most medical literature in this area of research has been descriptive and has focused on attitudes towards people with mental illness rather than on interventions to reduce stigma. In this narrative Review, we summarise what is known globally from published systematic reviews and primary data on effective interventions intended to reduce mental-illness-related stigma or discrimination.

[Comment] Sustainable development and global mental health—a Lancet Commission

In 2007, The Lancet published a groundbreaking Series on global mental health that ended with a call to action to scale up services for people with mental health problems guided by the twin principles of the right to evidence-based care and the right to dignity.1 This Series helped catalyse a movement that has raised the profile of mental health in public policies and promoted research, capacity building, and delivery of mental health care worldwide. The Series also influenced the launch of the Grand Challenges in Global Mental Health,2 which, in turn, inspired substantial funding commitments.

An up-close view of Indigenous health – good and bad

Professor Owler meets with staff at a remore community health service in the Northern Territory

By AMA President Professor Brian Owler

No running water, overcrowded and non-functional houses, lack of affordable healthy food, no essential services and crippling rates of diabetes, kidney disease and communicable infections – these are just some of the issues that people living in remote Northern Territory communities such as Utopia, Ampilatwatja and Kintore endure every day. On a recent visit to these three communities, I gained a deeper understanding of local health issues and the challenges that doctors and nurses face in delivering health services in remote areas.

In meeting with local Aboriginal leaders and health and medical staff, I found that each community has their own unique challenges; but the overall messages that I heard were strikingly similar. Funding for local health services is inadequate, it is difficult to attract skilled health and medical professionals to work in remote areas, it is logistically challenging to provide health care in remote communities (particularly when patients need to be transported for specialist care), and the level of chronic diseases in these communities are alarming.

Take diabetes, for example. In Kintore, 130 of the community’s approximately 450 residents have non-gestational diabetes – almost a third of its entire population – and in every three houses, one person is on dialysis due to the onset of kidney disease. What is even more concerning is the young age that Aboriginal people are being diagnosed with diabetes. In Utopia, a seven year-old girl was recently diagnosed with type 2 diabetes, and in Ampilatwatja, a 13 year-old girl was diagnosed with the same condition. Among the broader Australian population, or perhaps anywhere in the world, it is unheard of for child so young to be diagnosed with type 2 diabetes, yet it is clearly visible in remote Aboriginal communities.

The lack of water and affordable healthy food in remote communities is strongly linked to the epidemic levels of diabetes among Aboriginal people in these areas. Sugary drinks are more readily available than diet soft drinks, and in some communities they are more accessible than running water. It is unfathomable that in Australia, communities are going without water – a basic human right and a necessity for good health and wellbeing. This is an issue that demands immediate attention and action by all levels of government – without it, the health gap between Indigenous and non-Indigenous Australians will remain wide and intractable.

One important lesson that I did learn while visiting these communities is that it is not all doom and gloom when it comes to Indigenous health. Yes, Aboriginal people in remote areas face great adversity, but they are patient, resilient, strong-willed and are determined to take control of their own health – there are some real positives happening.

At the Purple House, an Aboriginal-controlled dialysis service based in Alice Springs, I was told an inspiring story of Aboriginal people taking action to generate funds for more dialysis sites. Kidney disease is rife across central Australia, with many Aboriginal people developing this condition as a result of poorly controlled diabetes.

The need for dialysis in remote Aboriginal communities is extremely high and for many, treatment means leaving family and country to be treated in Alice Springs. To allow people to be treated on country and near family, Aboriginal artists from across the western desert region grouped together and painted artworks that were auctioned to raise funds. The auction raised more than $1 million, and Purple House was able to expand their dialysis services. They now operate across nine remote communities in the Northern Territory and Western Australia. Purple House also provides a mobile dialysis service via their ‘Purple Truck’, which travels to remote Aboriginal communities.

It is very rare that good news stories such as this are widely publicised, which is disappointing. We need to shed more positive light on Indigenous health, and Indigenous affairs more broadly in Australia.

The POCHE Centre for Indigenous Health and Wellbeing in Alice Springs is also making a positive contribution to the health of Aboriginal people. At the POCHE Centre, I learnt about the research currently being undertaken by PhD candidate Maree Meredith, a young Aboriginal woman from Queensland. Her research project aims to determine the role that art centres play in contributing to positive health outcomes for Aboriginal people across the Anangu Pitjantjatjara Yankunytjatjara (APY) lands. To ensure that this research was in line with cultural protocols and to ensure that appropriate data was collected, Ms Meredith worked with Anangu people to design and deliver a survey in the local language.

For many years, anecdotal evidence has suggested art centres make a significant contribution towards health and wellbeing, but there has been no empirical data. This study aims to provide reliable evidence that art centres improve the health and wellbeing of Aboriginal people in remote communities. This is also a clear example of building the capacity of local Aboriginal people to participate in the local workforce.

Aboriginal people know what they want – they know the best way to improve their health and wellbeing, and this must be acknowledged and supported if we are to truly close the gap.

While in Kintore, I spoke with Aboriginal leaders who mentioned that the local people prefer a traditional social and emotional wellbeing framework to be implemented in their community, rather than a Western one.

The community developed a proposal for Government funding for this initiative, but unfortunately it was not accepted.

Connection to culture is important to the health and wellbeing of Indigenous people, and is known to produce positive health and life outcomes, such as reduced incarceration rates.

Aboriginal people needed to be provided with a reason to stay in the communities where they are connected to their land, culture and families. Recent comments made by certain members of Parliament about subsidising the ‘lifestyle choices’ of Aboriginal people in remote areas are extremely concerning.

Within each of these communities, I was disheartened to see a world-class health system fail the Aboriginal people in remote communities. But, I was truly impressed by the resilience and determination of the local Aboriginal people and the passion, commitment and dedication of doctors, nurses and other health staff who work tirelessly such challenging environments.

I am extremely grateful to Warren Snowden, Member for Lingiari, for making visits to these communities possible, and for accompanying me throughout the trip. I am hopeful that we will see further progress made in improving health and life outcomes for Indigenous people across Australia.

 

 

 

 

                       

[Correspondence] Iran, sanctions, and collaborations

In their letter, Rezaee-Zavareh and colleagues1 (Jan 2, p 28) ascertained that international collaboration in medical research was comparatively scarce in Iran, possibly because of sanctions, and argued that lifting sanctions might improve the quality and quantity of Iranian scientific research. Although this argument might be true, their figure1 shows that, in 2005–14, the rate of growth of international collaboration in Iran was similar to that in Israel and Egypt, lower than that in Saudi Arabia, and greater than that in Turkey, which was not under sanctions—suggesting that sanctions in Iran did not affect such collaboration.