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Cancer patients have increased risk of heart failure

Cancer patients have a high chance of heart failure within 12 months of diagnosis and subsequent chemotherapy treatment, a recent South Australian study has found.

The study of 15,987 patients identified 8,339 who received chemotherapy (817 children and 7,522 adults) subsequently received hospital treatment for heart failure, with 70 per cent of children and 46 per cent of adults having an index admission within 12 months of their cancer diagnosis.

The study, funded by the Heart Foundation, was led by Professor Robyn Clark, who is a senior fellow as well as Flinders University’s Professor of Acute Cardiovascular Care and Research in the College of Nursing and Health Sciences.

The research examined cardiac toxicity both quantitatively and qualitatively to gain greater understanding through a meta-review of 18 systematic reviews, linked data analysis, risk assessment, process mapping, patient interviews and a Consumer Consensus Statement.

Cardiotoxicity is a condition where there is damage to the heart muscle. It can be a complication from some cancer therapies, and as a result the heart may not be able to pump blood throughout the body as well.

“Despite being aware of this risk for over 30 years, currently there is no high-level evidence in Australia to guide clinician decision-making in the prevention, detection or management of cancer treatment associated cardiotoxicity,” Professor Clark said.

The findings from the study included the revelation that more men than women developed heart failure (48.6 per cent versus 29.5 per cent).  Also, heart failure (HF) patients had increased mortality risk compared with non-HF patients, with 47 per cent occurring within one year and 70 per cent within three years from cancer diagnosis.

The study recommends an increase for patient awareness of the risks and updating clinical guidelines aims to save lives and includes close heart monitoring. When patients receive a cancer diagnosis they should get a Heart Health Check with their GP and to work with their doctors to reduce their risk factors of heart disease.

Imelda Lynch, CEO Heart Foundation SA, believes it is vital to help clinicians identify cancer patients at greater risk of developing cardiac complications and, through early intervention, to improve patient outcomes.

“The impact of this research will be far-reaching and would not be possible without the generous donations the Heart Foundation receives from our wonderful community,” Ms Lynch said.

Professor Clark’s research was published on 17 October in the Cardio-Oncology journal.

MEREDITH HORNE

Research leads to innovative new lens

New research into eye health and the effect of prolonged exposure to digital devices has led to the introduction of innovative lenses designed to filter artificial blue light emitted from computer screens.

Crowd-funded Australian start-up EXYRA has developed a ground-breaking lens that blocks natural and artificial blue light from entering retinas and causing muscular and visual damage to the eyes.

The eye’s natural lens is not designed to filter artificial blue light from computer screens, tablets and other hi-tech devices.

Yet, as a society, Australians have become massively technology-dependent, with the average household using up to six different digital devices daily for two hours or more.

This includes for work, school and pleasure.

Prolonged exposure to such devices, more specifically the blue light emitted from LED screens, can be detrimental to overall eye health.

This can lead to a range of symptoms, including but not limited to, eyestrain, headaches, fatigue, neck and back pain, and blurred vision. 

The newly developed lenses, offered in a range of optical frames, are currently being used in non-prescription and prescription applications, but not yet as bi-focals or multi-focals.

The option exists, however, of upgrading lenses to include greater magnification, allowing the wearer to accommodate varying degrees of contrast without the need for excessive focussing effort.

The glasses are specially designed to optimise vision when viewing digital screens by reflecting high energy blue light and enabling healthier blue-turquoise wavelengths to enter the retina in order to enhance full colour perception and protect the eye from muscle strain.

The lens’s multi-layered construction also protects from UV damage, including glare.

CHRIS JOHNSON

[Seminar] Amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis is characterised by the progressive loss of motor neurons in the brain and spinal cord. This neurodegenerative syndrome shares pathobiological features with frontotemporal dementia and, indeed, many patients show features of both diseases. Many different genes and pathophysiological processes contribute to the disease, and it will be necessary to understand this heterogeneity to find effective treatments. In this Seminar, we discuss clinical and diagnostic approaches as well as scientific advances in the research fields of genetics, disease modelling, biomarkers, and therapeutic strategies.

[Review] An update on Zika virus infection

The epidemic history of Zika virus began in 2007, with its emergence in Yap Island in the western Pacific, followed in 2013–14 by a larger epidemic in French Polynesia, south Pacific, where the first severe complications and non-vector-borne transmission of the virus were reported. Zika virus emerged in Brazil in 2015 and was declared a national public health emergency after local researchers and physicians reported an increase in microcephaly cases. In 2016, WHO declared the recent cluster of microcephaly cases and other neurological disorders reported in Brazil a global public health emergency.

[Comment] Introducing a history of key trials in The Lancet

The introduction of randomised controlled trials (RCTs) by the UK Medical Research Council (MRC) in the 1940s constitutes one of the most important experimental advances in modern medicine.1 Through the examination of the efficacy—or otherwise—of drugs and other interventions, RCTs have become the essential scientific arbiter through which treatments are translated from the laboratory to the clinic. Meanwhile, the fundamental methods that underpin the RCT—quantitative thought and the basic principles of randomisation, replication, and unbiased observation—have led to improvements in health care and evidence-based medicine.

[Comment] A call for planetary health case studies

Planetary health investigates the human health impacts resulting from anthropogenic disruptions in the structure and function of earth’s natural systems.1,2 The Planetary Health Alliance and The Lancet invite researchers, educators, and decision makers to submit real-world examples of planetary health in action for further development into case studies. We seek examples that show how human disruptions of natural systems (eg, the climate system, specific ecosystems, not solely unaltered ecosystems) can lead to increased burden of disease and show how a better understanding of these connections can lead to interventions or policies with positive health outcomes.

Lead poisoning a top risk factor for pre-eclampsia

More than a century since a Brisbane doctor found that lead in paint destroyed children’s lives, new research from Griffith University concludes that it is a major risk factor for pre-eclampsia. 

Pre-eclampsia is a disease which kills more than 75,000 women around the world each year and is responsible for 9 per cent of all fetal deaths.

Scientists from Griffith University have published their findings in Environmental Research, which measured blood lead levels of pregnant women who experienced pre-eclampsia and control groups of women who did not experience preeclampsia. 

“We combined the data from a number of clinical trials to conduct a powerful analysis of pre-eclampsia research,” said Dr Arthur Poropat from Griffith Health. 

Along with Dr Mark Laidlaw from RMIT University, the team found that blood lead levels are the strongest predictor of whether a pregnant woman will develop pre-eclampsia, with even relatively low levels of lead increasing the risk of the condition.

“There is a clear dose-response relationship between maternal blood lead and pre-eclampsia: doubling the blood lead level results also doubles the risk of pre-eclampsia,” Dr Poropat said.

Pre-eclampsia is a potentially fatal disease, in which pregnant women develop high blood pressure and protein in their urine due to kidney malfunction, potentially leading to cardiac and/or kidney failure, and eventual disability or death. 

Reducing exposure to lead remains an important health issue in Australia because lead can be found in various sources throughout the environment. 

Dr Poropat said women are exposed to lead in many ways, including lead paint, lead contaminated soils, lead water pipes, shooting lead bullets at firing ranges and other sources. Women can even be exposed by handling or washing lead contaminated clothes.

“Fortunately, most people in Australia are not at risk of lead poisoning as they are not commonly exposed to lead via their occupation or the environment. However there are certain well-documented risk areas within the country including the industrial regions of Broken Hill (NSW/SA), Mount Isa (QLD) and Port Pirie (SA). 

“Regardless of where women are located or their lifestyle, women should be aware of the risks associated with lead poisoning if they are preparing to become pregnant or are currently pregnant,” Dr Poropat said.

Lead, a naturally occurring metal found in the earth’s crust, has a wide variety of uses in manufacturing. Unlike many other naturally found metals, lead and lead compounds are not beneficial or necessary for human health, and can be harmful to the human body. Infants, children and pregnant women are at the greatest risk of harm from lead.

Professor Mark Taylor from Macquarie University in Sydney led a study that was published earlier this year which was the first comprehensive snapshot of industrial lead contamination in Australia.

This study found that while concentration of lead in the air in major cities is now largely below limits of detection, contaminated soil and dust is causing problems in backyards. 

Professor Taylor believes that regulation has reduced concentrations of lead in air largely below limits of detection in our major cities. However, he warns homeowners need to be careful, especially if they live in the inner city or have homes built before the 1970s.

MEREDITH HORNE

Ground-breaking lymphoma treatment advanced with genomics research

The Christine and Bruce Wilson Centre for Lymphoma Genomics has been launched at the Peter MacCallum Cancer Centre and partnered with The University of Melbourne to deliver groundbreaking and innovative advancement for Australian lymphoma patients.

The Centre will establish a team of clinicians, pathologists and scientists dedicated to utilising lymphoma genomics to improve outcomes in patients with lymphoma and related malignancies.

The Centre will aim to provide translational clinical-grade genomic testing for patients with lymphoma and related lymphoid malignancies treated at the Victorian Comprehensive Cancer Centre (VCCC), in order to influence therapeutic choice and personalise the treatment of patients with lymphoid blood cancers.

Genomics testing involves testing a patient’s blood for critical gene mutations, enabling doctors to create a personalised, targeted treatment for individual patients.

Associate Professor David Westerman, who will lead the research project, says the advancement of genomics will eventually eliminate the need for chemotherapy in treating cancer.

“With this partnership between research, clinical, university and philanthropy, we are now able to fast-track genetic testing to more patients and monitor the effectiveness of treatments,” he said.

“Genomics and personalised medicine is what will aid targeted, less toxic cancer treatments.”

The ground-breaking project was enabled through a generous $5 million donation by Christine and Bruce Wilson, which followed Christine’s personal experience as a patient living with lymphoma for 25 years. They were struck by how genetics testing can save lives, or improve quality of life, for a group of patients who are in dire need of other treatment options.

“I have been fortunate enough to experience the benefits of this cutting-edge technology. My family hopes that our support will make the Centre’s ground-breaking work accessible to all Australians affected,” Christine Wilson said.

Blood cancers are the third leading cause of death by cancer in Australia. Each year more than 12,000 Australians are told they have blood cancer, according to the Australian Institute of Health and Welfare.

Blood cancers like lymphoma often result from spontaneous mutations that occur as the body makes new blood cells, and one reason they can be so difficult to properly diagnose and treat is because so much can go wrong.

MEREDITH HORNE

Improving bipolar disorder with computers

A Harvard study has shown for the first time that computerised brain training can result in improved cognitive skills in individuals with bipolar disorder.

In a paper published in the October 17, 2017 edition of The Journal of Clinical Psychiatry, the researchers suggest that brain exercises could be an effective non-pharmaceutical treatment for helping those with bipolar disorder function more effectively in everyday life.

The researchers found that the cognitive exercise regimen from BrainHQ online brain exercises and computer apps drove a large improvement in a standard measure of overall cognitive ability, as well as significant improvements in other cognitive measures.

Participants in the study also showed a large gain on the sub-domain measure of memory and visual learning, and a trend toward a medium-sized gain in the sub-domain of speed of processing.

The researchers assessed study participants again six months after the training ended, and they found that the gain in overall cognition persisted and that there was even a slight further improvement.

Lead investigator for the study, Dr Eve Lewandowski, said problems with memory, executive function, and processing speed are common symptoms of bipolar disorder and have a direct and negative impact on an individual’s daily functioning and overall quality of life.

“Improving these cognitive dysfunctions is crucial to helping patients with bipolar disorder improve their ability to thrive in the community,” Dr Lewandowski said.

The authors believe the findings demonstrate this type of non-pharmaceutical intervention can significantly improve cognition in patients with bipolar disorder, as well as suggesting that once the brain is better able to perform cognitive tasks, it will continue to strengthen those processes even after patients stop using the treatment.

While medications are available that help with the mood symptoms of bipolar, the authors identified that there are no current medications that help improve cognitive function. Some prior studies have been done with cognitive training in bipolar disorder, but such studies have often been small and lacked control groups.

Dr Lewandowski believes that this novel approach using computerised brain training, once fully developed, will be able to offer affordable and easily accessible web-based interventions which will be effective for a broad group of patients.

The study was conducted by independent researchers at Harvard Medical School and McLean Hospital, an affiliate of Harvard Medical School.

SANE Australia believes up to one person in 50 will develop bipolar disorder at some time in their lives.

MEREDITH HORNE

Productivity Commission recommends big changes to health system

Australians are living longer than people in most other developed countries, but they are also spending longer periods in ill health.

That is one finding of the Productivity Commission’s five-year review, released in October and titled Shifting the Dial.

It also found that most Australians have great confidence in the health care they receive.

The report has recommended, however, a dramatic adjustment to the nation’s health system, with reforms that could save more $140 billion over 20 years.

Poor communication between healthcare professionals – GPs and public hospitals in particular – has contributed to problematic issues faced by patients, the report finds.

And it suggests supervised vending machines could replace community pharmacy roles in dispensing medicines in some locations.

“Australians are living longer, with less disability than ever before. Australia outranks most other highly developed economies in health outcomes,” the report states.

“It has the third greatest life expectancy at birth among OECD countries in 2015 at 82.8 years and a high absolute number of years spent in good health (though a lower than expected number given our life expectancy)…

“Indeed, Australia has one of the highest obesity rates in the world, and it appears to be still rising. And while Australians have high life expectancy, they also have the highest number of years spent in ill-health compared with other OECD countries.”

According to the review, the overwhelming share of Australians had confidence they would receive quality and safe medical care, effective medication and the best medical technology if they were seriously ill.

Australia is faring comparatively well by international benchmarks in certain areas of preventative health — most notably in reducing rates of smoking and transport accident deaths.

“On face value, the cost effectiveness of Australia’s health system also appears relatively high compared with other OECD countries, with Australia spending less on health than many countries for comparable or better outcomes in life expectancy,” it states.

Yet Productivity Commission chairman Peter Harris described a “non-existent communication” between different parts of the health system that has led to many problems.

He has recommended to the Federal Government that it undertake a significant overhaul of how the sector functions.

“A simple indicator of service integration is the proportion of a hospital’s patients whose GPs are provided with a discharge summary within 24 hours of discharge,” his report states.

“Currently, Australia’s performance appears poor. Less than 20 per cent of Australian GPs were always told when a patient was seen in an emergency department compared with 68 per cent in the Netherlands, 56 per cent in New Zealand and 49 per cent in the United Kingdom.

“Clinicians, patients and researchers operate under a veil of ignorance posed by inadequate information flows and haphazard data collection. Private health insurance sits uneasily with a system of public insurance, with their respective roles weakly defined.

“The imperative is therefore better coordination of the system, giving a greater weight to the role of public health, and acceptance of people themselves as partners in their own health management.”

GPs are the clinicians that Australians most frequently see and are highly trusted, the report states.

It says all Australian governments should re-configure the healthcare system around the principles of patient-centred care, and implement changes within a five-year timeframe.

Australian governments are urged to cooperate to remove the current “messy, partial and duplicated presentation of information and data” and provide easy access to healthcare data for providers, researchers and consumers.

And the review recommends the Federal Government end community pharmacy as the vehicle for dispensing medicines and move towards a model that anticipates automatic dispensing in a majority of locations.

This would be supervised by a suitably qualified person. In clinical settings, pharmacists should play a new remunerated collaborative role with other primary health professionals where there is evidence of the cost-effectiveness of this approach.

An alcohol tax system that removes the current concessional treatment of high-alcohol, low-value products, primarily cheap cask and fortified wines, should also be embraced.

The uptake of technologies that could lower costs and increase convenience and quality has often been slow, the review found.

“Telehealth is still in its infancy, and restrictions in payment models frustrate its diffusion,” it states.

“More generally, the adoption of eHealth has had a protracted and troubled history in Australia that is only now beginning to be resolved. The old chestnuts — the anti-competitive regulation of the professions and the incongruities presented by retail pharmacy regulations have proved resistant to repeated calls for reform.”

The imperative for policy action is justified on many counts, according to the review. It says such action will produce better health outcomes and wellbeing, provide more voice to and choice for patients, and result in greater efficiency.

“Wasteful expenditure means that resources are being used in the wrong places to no or little effect on health outcomes,” the report says.

In launching the Productivity Commission’s findings, Federal Treasurer Scott Morrison said the review would make governments and the health sector consider the effectiveness of the health system.

“Improving the health of Australians is not just about enhancing our quality of life; it’s an economic growth strategy,” Mr Morrison said.

“Healthy and happy people are naturally more productive people.”

The full report can be found at: https://www.pc.gov.au/inquiries/completed/productivity-review/report

CHRIS JOHNSON