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[Comment] Preprints with The Lancet: joining online research discussion platforms

From June, 2018, the Lancet family of journals are starting a 6-month trial in collaboration with the freely accessible preprint platform SSRN, which has been part of Elsevier since May, 2016. With this pilot, we are interested to see whether health and medical researchers are ready for this form of sharing work early in the research or publication process.

[Seminar] Type 1 diabetes

Type 1 diabetes is a chronic autoimmune disease characterised by insulin deficiency and resultant hyperglycaemia. Knowledge of type 1 diabetes has rapidly increased over the past 25 years, resulting in a broad understanding about many aspects of the disease, including its genetics, epidemiology, immune and β-cell phenotypes, and disease burden. Interventions to preserve β cells have been tested, and several methods to improve clinical disease management have been assessed. However, wide gaps still exist in our understanding of type 1 diabetes and our ability to standardise clinical care and decrease disease-associated complications and burden.

[Editorial] Turning Brexit uncertainties into public health advancement

This June 23 issue of The Lancet falls on the second anniversary since the UK European Union (EU) membership referendum altered the course of European history: throwing prospects for health, medicine, and scientific research into uncertainty against a backdrop of heightened feelings. 2 years later, few bodies have clear plans for their post-Brexit strategies. The European Medicine Agency’s building relocation from London to Amsterdam is on track for completion by March, 2019, but the agency has made no progress towards redefining its relationship with the UK.

[Correspondence] Cross-border collaboration and an advanced gastrointestinal endoscopic unit in Gaza

Knowledge and its production have no national borders. Collaboration between researchers and teams from different countries happens all the time. Such collaborations should be driven by scientific considerations and should not be constrained by administrative issues. Cross-border collaboration involves a degree of interoperability and common approaches based on mutual trust and understanding between organisations that often operate in diverse scientific and legal environments. This Correspondence discusses a successful Israeli–Palestinian collaboration that is benefiting hundreds of people in the Gaza Strip.

[Editorial] France may be back, but the old ways persist for INSERM

On June 12, the term of the Chief Executive Officer (CEO) of the French National Institute of Health and Medical Research (INSERM) ends. The office of the current CEO, Yves Lévy, came under heavy criticism after the appointment of the minister of health, Agnès Buzyn, in May, 2017. Lévy is Buzyn’s husband, an obvious potential conflict of interest for the head of an institute that is run under the dual auspices of the Ministries of Health and Research. This discrepancy was seemingly rectified, on May 29, 2017, by a decree stating that acts relating to INSERM would be carried out by the French prime minister, not Buzyn.

[Perspectives] The genesis of the Global Burden of Disease study

In 1997 The Lancet published “Mortality by cause for eight regions of the world: Global Burden of Disease Study”. This Global Burden of Disease (GBD) study was the first in a series of four articles that ushered in a new era in descriptive epidemiology, and launched the ascendancy of the GBD in the then nascent field of global health. The four landmark papers gave the GBD study and its authors, Christopher Murray and Alan Lopez, scientific credibility and exposure in the scientific community.

[Obituary] Alberto Zanchetti

Global leader in hypertension research. He was born in Parma, Italy, on July 27, 1926, and died of a brain haemorrhage in Milan, Italy, on March 24, 2018, aged 91 years.

[Perspectives] Destroyed but not defeated—The Old Man and the Sea

Do traits like positivity, stubbornness, and hard work affect longevity? One study of Italian nonagenarians and centenarians suggested that the answer is yes. Researchers reported that, despite their declining physical health, this group of older Italians continued to control their social lives and refused to stop working the land. Their “exceptional longevity”, the authors suggested, was intimately linked to “a balance between acceptance of and grit to overcome adversities”, and a commitment to their purpose in life.

The Canadian Partnership for Tomorrow Project: a pan-Canadian platform for research on chronic disease prevention [Research]

BACKGROUND:

Understanding the complex interaction of risk factors that increase the likelihood of developing common diseases is challenging. The Canadian Partnership for Tomorrow Project (CPTP) is a prospective cohort study created as a population-health research platform for assessing the effect of genetics, behaviour, family health history and environment (among other factors) on chronic diseases.

METHODS:

Volunteer participants were recruited from the general Canadian population for a confederation of 5 regional cohorts. Participants were enrolled in the study and core information obtained using 2 approaches: attendance at a study assessment centre for all study measures (questionnaire, venous blood sample and physical measurements) or completion of the core questionnaire (online or paper), with later collection of other study measures where possible. Physical measurements included height, weight, percentage body fat and blood pressure. Participants consented to passive follow-up through linkage with administrative health databases and active follow-up through recontact. All participant data across the 5 regional cohorts were harmonized.

RESULTS:

A total of 307 017 participants aged 30–74 from 8 provinces were recruited. More than half provided a venous blood sample and/or other biological sample, and 33% completed physical measurements. A total of 709 harmonized variables were created; almost 25% are available for all participants and 60% for at least 220 000 participants.

INTERPRETATION:

Primary recruitment for the CPTP is complete, and data and biosamples are available to Canadian and international researchers through a data-access process. The CPTP will support research into how modifiable risk factors, genetics and the environment interact to affect the development of cancer and other chronic diseases, ultimately contributing evidence to reduce the global burden of chronic disease.

Mr Hunt, are we there yet?  Continuing the public hospital funding journey

BY DR RODERICK MCRAE, CHAIR, AMA FEDERAL COUNCIL OF PUBLIC HOSPITAL DOCTORS 

By the time of this column’s publication, we may have had some further information from the Federal Minister for Health Greg Hunt, at the AMA’s National Conference, although the Budget is pretty fresh. We know public hospitals are fundamental to Australia’s overall health system, dealing with greater than six million admitted patient care episodes and around 92 per cent of emergency admissions in any one year. Nonetheless, we experience chronic under-funding partially because of near stagnant growth in financial support. This has been going on for just too long; we all feel the pressure day in, day out.  We know under-funding is building to crunch point.

AMA’s 2018 Public Hospital Report Card shows bed numbers per 1000 population are static; performance, basically, is plateauing at best; waiting lists, you know the sorry truth about that and our patients are suffering!  My December 2017 Australian Medicine column criticised the Council of Australian Government’s (COAG) savage imposed financial penalties where avoidable re-admissions or hospital-acquired complications are deemed to have occurred. The AMA’s 2016 Safe Hours Audit shows that in public hospitals, 53 per cent of doctors are at “significant risk” of fatigue with dangerous fatigue levels being reported across a raft of specialty groups.

So, the effect of underfunding is cumulatively adding up to seriously affecting our, and the system’s, ability to perform optimally for our patients, and our own health and wellbeing is at stake. That’s why the 2018 Budget decisions matter; it’s about what the future holds for public hospital medicine. Without vital new investment, required infrastructure, and human resource capacity, an appropriate standard of result cannot happen.

Reflecting on AMA’s pre-budget submission, what we have said is that the Budget must fully fund, for the medium to long term, internal capacity building and expansion of their integrated care responsibility.  Not to penalise an already underfunded sector via that sneaky COAG device that will redirect otherwise committed funds.  The AMA also says States and Territories must be fully compensated for any loss in private patient revenue and any funding decisions must not dilute support for patients electing private treatment. Mr Hunt has said he intends to look at these private patient issues so we don’t yet know where Government is headed.

Despite the known pressure on public hospitals the new 2020-25 Hospital Funding Agreement ratchets up this financial pressure on hospitals even further. Within existing levels of Federal funding, the Agreement will require public hospitals to implement new measures to cut waste, increase productivity and extend their responsibilities to engage in the care of chronically ill-patients post discharge to reduce overall admissions.

I agree integrated care is essential – but this work requires new Federal funding to pay for the hospital and primary sector resources required to deliver it. The public hospital funding in the 2018 Federal Budget was nothing more than the amount forecast over the forward estimates to maintain funding at current levels. 

There are many laudable new funding initiatives out of this Budget, to name some: a rural doctor workforce/training package, increased support for aged care in the home, and mental health/suicide prevention services, new research investment and (perhaps laughable!) the “unfreezing” of Medicare indexation. However, the Budget lacks consideration of how any savings from the Government’s yet to be finished MBS reviews will be re-invested into public health, and we still wait on needed big structural reform. There must also be funds to urgently begin development of a national medical workforce strategy.  On that, your Council of Public Hospital Doctors is working through the AMA to encourage all jurisdictions to cooperate more closely in their planning and coordinating of our future medical workforce to meet Australia’s future healthcare needs.

There’s an election coming; maybe this year; and Labor has promised an additional $2.8 billion ‘better hospitals’ fund to target reducing elective surgery waiting times and increasing emergency department bed numbers. Your CPHD will be looking to score both major parties as they release more health policy and keep a watching on eye on any moves to change public hospital private practice arrangements. We must push for the government to match Labor’s pledge and make Government fund for growth, not just, as it has been, keeping pace with activity. It’s matching funding with growth and having a workforce plan that really matters!