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[Correspondence] Selected and non-selected non-communicable diseases

I was delighted to see the excellent Series paper by Melanie Y Bertram and colleagues (May 19, p 2071)1 dealing with economic issues related to non-communicable diseases, and read the Comments by Richard Horton and Jennifer Sargent2 and by the WHO Director General, Tedros Adhanom Ghebreyesus,3 with much admiration.

Racial diversity of physicians in the USA

In the United States, racial and ethnic minorities have higher rates of chronic disease, obesity, and premature death than white people.

Black patients, in particular, have among the worst health outcomes, experiencing higher rates of hypertension and stroke. And black men have the lowest life expectancy of any demographic group, living on average 4.5 fewer years than white men.

The Harvard Business Review says that a number of factors contribute to these health disparities, but one problem has been a lack of diversity among physicians.

African Americans make up 13 per cent of the US population, but only four per cent of US doctors and less than seven per cent of US medical students. Of active US doctors in 2013, 48.9 per cent were white, 11.7 per cent were Asian, 4.4 per cent were Hispanic or Latino, and 0.4 per cent were Native American or Alaska Native.

Research has found that physicians of colour are more likely to treat minority patients and practise in underserved communities. And it has been argued that sharing a racial or cultural background with one’s doctor helps promote communication and trust.

A new study from the National Bureau of Economic Research looked at how changing this ratio might improve health outcomes – and save lives.

Researchers set up an experiment that randomly assigned black male patients to black or non-black male doctors, to see whether having a doctor of their race affected patients’ decisions about preventive care.

They found that black men seen by black doctors agreed to more, and more invasive, preventive services than those seen by non-black doctors. And this effect seemed to be driven by better communication and more trust.

Increasing demand for preventive care could go a long way toward improving health. A substantial part of the difference in life expectancy between white and black men is due to chronic diseases that are amenable to prevention.

By encouraging more preventive screenings, the researchers calculate, a workforce with more black doctors could help reduce cardiovascular mortality by 16 deaths per 100,000 per year – resulting in a 19 per cent reduction in the black-white male gap in cardiovascular mortality and an 8 per cent decline in the black-white male life expectancy gap.

 

DNA to predict disease risk

Scientists have created a powerful new tool to calculate a person’s inherited risks for heart disease, breast cancer, and three other serious conditions.

Reporting on research in the journal, Nature Genetics, the New York Times revealed that, by surveying changes in DNA at 6.6 million places in the human genome, investigators at the Broad Institute and Harvard University were able to identify many more people at risk than do the usual genetic tests, which take into account very few genes.

Of 100 heart attack patients, for example, the standard methods will identify two who have a single genetic mutation that place them at increased risk. But the new tool will find 20 of them.

The researchers are now building a website that will allow anyone to upload genetic data from a company like 23andMe or Ancestry.com. Users will receive risk scores for heart disease, breast cancer, Type 2 diabetes, chronic inflammatory bowel disease, and atrial fibrillation.

People will not be charged for their scores.

A risk score, including obtaining the genetic data, should cost less than $100, said Dr Daniel Rader, a professor of molecular medicine at the University of Pennsylvania.

Dr. Rader, who was not involved with the study, said the university will soon be offering such a test to patients to assess their risk for heart disease. For now, the university will not charge for it.

Dr Sekar Kathiresan, senior author of the new paper and director of the Center for Genomic Medicine at Massachusetts General Hospital, said his team had validated the heart risk calculation in multiple populations.

But DNA is not destiny, Dr Kathiresan stressed. A healthy lifestyle and cholesterol-lowering medications can substantially reduce risk of heart attack, even in those who have inherited a genetic predisposition.

The new tool also can find people at the low end of the risk range for the five diseases. This should prove useful to certain patients: for example, a woman who is trying to decide when she should start having regular mammograms, or a 40-year-old man with a slightly high cholesterol level who wants to know if he should take a statin.

 

Doctor Robot  

 

The Guardian reports that robots could soon help hospital patients eat their meals, diagnose serious illnesses, and even help people recover from operations, in an artificial intelligence revolution in the NHS in the UK.

Machines could take over a wide range of tasks currently done by doctors, nurses, health care assistants, and administrative staff, according to a report prepared by the Institute for Public Policy Research (IPPR) and eminent surgeon and former Health Minister, Lord Darzi.

Widespread adoption of artificial intelligence (AI) and ‘full automation’ by the NHS could free up as much as £12.5 billion a year worth of staff time for them to spend interacting with patients, according to the report.

“Given the scale of productivity savings required in health and care – and the shortage of frontline staff – automation presents a significant opportunity to improve both the efficiency and the quality of care in the NHS,” the report says.

“Bedside robots could help patients consume food and drink and move around their ward, and even help with exercises as part of their rehabilitation from surgery.

“In addition, someone arriving at hospital may begin by undergoing digital triage in an automated assessment suite.

“AI-based systems, include machine-learning algorithms, would be used to make more accurate diagnoses of diseases such as pneumonia, breast and skin cancers, eye diseases, and heart conditions.

“Digital technology could also take over the communication of patients’ notes, booking of appointments, and processing of prescriptions.”

The report sought to allay fears of significant job losses, signaling that machines would work alongside human beings, not replace them, so patients would benefit.

[Comment] The Lancet–EASL Commission on liver diseases in Europe: overcoming unmet needs, stigma, and inequities

Worldwide, liver diseases are on the rise. As an example, death rates from viral hepatitis now outnumber those from HIV/AIDS.1 The Lancet Commission on liver disease in the UK provided evidence that standardised UK mortality attributable to liver diseases has risen four-fold between 1980 and 2013,2 with liver disease likely to overtake ischaemic heart disease as the leading cause of years of working life lost.3 In addition to varying trends in mortality (figure),4,5 there are substantial differences in how the management of patients is organised within health systems.

To keep patients safe in hospitals, the accreditation system needs an overhaul

Once a year, inspectors visit hospitals across the country to assess their performance on a range of measures, from medication safety to consumer engagement. But it’s not a secret shopper-type scenario. Hospital staff have known for months when the inspectors will arrive and what they will be looking for.

It’s no wonder doctors dismiss the process as irrelevant or a waste of their time. But most concerning is the process doesn’t identify the key safety issues in hospitals, nor propose ways to address them.

Almost every significant safety failure in Australian hospitals in recent decades has happened in a hospital that had passed accreditation with flying colours.

Bundaberg Hospital passed accreditation, despite allowing surgeon Jayant Patel (later dubbed Dr Death) to continue practising after complaints from patients and staff about his competence.

Bacchus Marsh Hospital, where seven babies died after receiving sub-optimal care, had regularly passed accreditation. The hospital was about to get a new accreditation certificate when the story broke.

And Bankstown-Lidcombe Hospital in New South Wales, where a gas mix-up left one baby dead and another brain-damaged, was accredited.

A new Grattan Institute report shows how accreditation needs to change. Australia’s one-size-fits-all system of assessing hospitals against centrally determined “standards” must be replaced with a system tailored to address the specific weaknesses of each hospital.

The report shows that a hospital’s performance in one specialty is unrelated to its performance in another – a hospital may have the lowest rate of surgical complications in orthopaedics, but the highest rate of medication complications in general medicine.

One size fits all system

Some 40 years ago, I evaluated Australia’s relatively new hospital accreditation system for my PhD. Back then, hospitals were expected to meet a set of standards. Inspectors visited a hospital to assess it against the standards. They produced a report, which remained secret.

An independent body would make an assessment of the report, and the assessment also remained secret. Then, in almost every case, the hospital was awarded “accreditation”.

Inexcusably, today the process remains the same (though we do have better standards and a better report). No other part of Australia’s hospital system has been so immune from fundamental change over those 40 years.

Back then it was difficult to measure a hospital’s performance on patient complications, and the quality of care. This was partly because we didn’t know whether a patient had a particular diagnosis when they were admitted to the hospital, or whether the diagnosis arose because of something that happened in hospital.

We couldn’t compare one hospital with another hospital, so we had to rely on independent qualitative judgements.

Not any more. Today we can measure hospital complication rates and other safety indicators to assess a hospital’s performance and compare them with others. 

The dangers of a one-size-fits-all accreditation system can be illustrated by considering infection control, which is one of the current national standards for hospitals.

Hospital-acquired infections are widespread – more than one in every hundred patients contract one – and cost the hospital system almost A$1 billion each year.

The accreditation visit to the hospital with Australia’s lowest hospital-acquired infection rate will look very similar to the visit to the hospital with the highest rate. The same information will be read, people in the same roles will be interviewed, and the same boxes about identifying the problems and training staff will be ticked.

But the hospital with the worse infection record will have no way of learning from the best performer, and infection rates across the system will be unlikely to improve.

Tailoring accreditation

A new accreditation system needs to be tailored to each hospital’s situation.

All hospitals – public and private – should be given data about their complication rates and how they compare to other hospitals. The data provided to each hospital should be so specific that the hospital’s orthopaedic unit, for example, can compare its complication rates with its peers.

Hospitals and their clinical units should then develop plans to reduce their complications rates:

hospital accreditation cycle, Grattan Institute

The proposed new accreditation cycle would focus on enhancing the safety and quality of patient care.
Grattan Institute

Under the plan, hospitals would no longer be spruced up for a scheduled, visit by accreditation inspectors every few years. Instead, surveyors would visit without notice. The surveyors would focus on providing feedback to the hospital on how it can strengthen its own safety processes.

After each visit, the survey report should be released publicly. That way, patients and their families and GPs could make better-informed decisions about which hospitals to go to.

The cycle of visit and report should be repeated every few years. 

This dramatic change to the way Australia’s hospitals are accredited cannot occur overnight. Data has to be provided to hospitals in an actionable form, staff have to be trained in how to understand statistical variation and how to implement improvement strategies, and the new model needs to be piloted and evaluated.

But the sooner we make the transition, the better we’ll be able to care for Australians who have to go into hospital.

 

This article was originally published on The Conversation. Read the original article.

[Comment] Initiation of Global Burden of Animal Diseases Programme

A consistent and comparable description of animal diseases, the risk factors associated with them, and the effectiveness of intervention strategies to mitigate these diseases are important for decision making and planning. The economic impact of a pathogen or animal disease is a function of disease frequency, infection intensity, the effect of the disease on mortality and productivity in animals and its effects on human health, and efforts to respond to the disease.1 All of these factors can vary over time between species and the contexts in which people and animals live, and need to be measured to understand the patterns of impact at local, national, and global levels.

Polio in PNG

In a recent article in the Lowy Institute’s The Interpreter, Kaveri Devi Mishra explained how the news of pulse polio resurfacing in Papua New Guinea has created new challenges for a public health care system already confronting many related health problems.

Polio virus is a potentially deadly disease that can spread through communities, causing paralysis and disability, mostly among vulnerable young children.

The World Health Organization (WHO) has confirmed the outbreak, almost 18 years since PNG was declared a polio-free nation.

Papua New Guinea is already ranked by the WHO as having the worst health status in the Pacific region.

The polio outbreak comes at a time when the country is also facing huge challenges from diseases such as malaria, tuberculosis (TB), cancer, diarrhoeal diseases, pneumonia, and HIV/AIDS.

By landmass, population and economy, PNG is the largest nation among Pacific island countries, yet the country’s health indicators have either stalled or gone backwards over the past 30 years.

There is only one doctor per 17,068 people in PNG, which is exceedingly insignificant.

PNG has 0.58 health workers per 1000, whereas the WHO recommends 2.5 health professionals per 1000 people for maintaining primary health care.

Ms Mishra says that India might offer a model for eradication. While it was once a hotbed for the polio virus, a massive, nationwide campaign of eradication in India saw it eventually declared polio-free in 2011.

But precautionary measures are still in place. Given India’s population is 1.2 billion and PNG’s is only 8 million, surely PNG can likewise apply stringent measures against polio

CSIRO whacks Aussie mozzies

CSIRO reports that one of the world’s most widespread disease- spreading mosquitoes, the Aedes aegypti, has been suppressed by more than 80 per cent in a landmark Australian trial.

In an international partnership between CSIRO, Verily, and James Cook University, scientists used specialised technology to release millions of sterilised male Aedes aegypti mosquitoes across the Cassowary Coast in Queensland in a bid to combat the global pest.

CSIRO Director of Health and Biosecurity, Dr Rob Grenfell, said the results were a major win in the fight against disease- spreading mosquitoes.

“The invasive Aedes aegypti mosquito is one of the world’s most dangerous pests, capable of spreading devastating diseases like dengue, Zika, and chikungunya, and responsible for infecting millions of people with disease around the world each year,” Dr Grenfell said.

“Increased urbanisation and warming temperatures mean that more people are at risk, as these mosquitoes, which were once relegated to areas near the equator, forge past previous climatic boundaries.

“Although the majority of mosquitoes don’t spread diseases, the three mostly deadly types – the Aedes, Anopheles and Culex – are found almost all over the world and are responsible for around

17 per cent of infectious disease transmissions globally.”

From November 2017 to June this year, non-biting male Aedes aegypti mosquitoes sterilised with the natural bacteria Wolbachia were released in trial zones along the Cassowary Coast in North Queensland.

They mated with local female mosquitoes, resulting in eggs that did not hatch and a significant reduction of their population.